Description
Kollidon SR is a polyvinyl acetate and povidone based matrix retarding agent. It is particulartly suitable for the manufacturing of pH-independent sustained-release matrix tablets by direct compression. Polyvinyl acetate is a very plastic material that produces a coherent matrix even under low compression forces. When the tablets are introduced into gastric or intestinal fluid, the water soluble providone is leached out to form pores through which the active ingredient slowly diffuses outwards. Kollidon SR contains no ionic groups and is therefore inert to drug substances. The sustained-release properties are unaffected by ions and salts.